MRC LMB.
After graduating from Ecole Polytechnique (France) in 2013, Juliette did her PhD at Institut Pasteur Paris under the supervision of Felix Rey. Using X-ray crystallography and biochemical assays, she identified the ancient eukaryotic protein HAP2 as the first known gamete membrane fusion. In 2017, Juliette joined the cryo electron tomography group of Friedrich Förster (Utrecht University, Netherlands) for her postdoc. Her work characterized the different specialized ER translocon complexes, as well as their spatial organisation on native membranes. Juliette further implemented Focused Ion Beam milling approaches to study mRNA translation and its reorganization upon ribosome collision stress in intact mammalian cells. These studies revealed a higher diversity of ribosome complexes than previously anticipated from purified samples and identifiedpotentially limiting steps in collision response. In 2023 Juliette started her group at the MRC-LMB Cell Biology Division, where she uses cryoET approaches to study cellular proteostasis in health and diseases.
