9:00 Registration & Coffee
9:25 David Barford: MRC Laboratory of Molecular Biology
Welcome and Introduction
Session I – Nanocages and Molecular Assemblies
Chair: Chris Johnson, Co-Chair: Stephen McLaughlin
9:30 Jonathan Heddle, University of Durham, UK:
Understanding and building nanomachines from biological molecules
10:00 Lorna Dougan, University of Leeds, UK:
Engineering living hydrogels: from folded proteins to functional protein networks
10:30 Hendrik Dietz Technical University Munich, Germany:
Virus Traps and Other Molecular Machines of the Future
11:00 Coffee Break
Session II – Imaging Across Scales
Chair: Maria Flocco, Co-Chair: Chris Johnson
11:30 Sonja Hess, AstraZeneca, USA:
Integrated Analysis of N-Glycoproteomic and Global Proteomic of Human High-grade Glioblastoma Reveals Distinct Disease Signatures with Potential Clinical Implications
12:00 Radu Aricescu, MRC Laboratory of Molecular Biology, UK:
One needs more structural tools to solve complex biological puzzles
12:30 Clemens Kaminski, University of Cambridge, UK:
Dynamic imaging of organelle dynamics with optical super resolution
1:00 Lunch Break
Session III – Single Molecule Applications
Chair: Chris Batters, Co-Chair: Geoff Holdgate
2:00 Kasia Tych, University of Groningen, Netherlands:
Using single-molecule optical tweezers to study transmembrane proteins – an unfolding story
2:30 Sebastian Deindl, Uppsala University, Sweden:
Illuminating the regulation of gene expression at the single-molecule level
3:00 Coffee Break
Session IV – Nucleic Acid Chemistry and Dynamics
Chair: Geoff Holdgate, Co-Chair: Chris Batters
3:30 Andres Ramos, Institute of Structural and Molecular Biology, UCL, UK:
mRNA modification – from bench to neuron
4:00 Marina Kuimova, Imperial College London, UK:
Mapping microscopic viscosity and temperature using molecular rotors
4:30 Amanda Hargrove, Duke University, USA:
Modulating the conformation and function of disease-relevant RNA with small molecules
5.00 Break
Keynote Lecture
Chair: Maria Flocco, Co-Chair: Stephen McLaughlin
5:10 Matthias Mann, Max-Planck Institute of Biochemistry, Germany:
Technological advances in MS-Based proteomics: Deep Visual and Single Cell Proteomics for precision medicine
6.10 Jan Lowe, Laboratory of Molecular Biology, MRC, UK
Closing remarks
6:15 Drinks Reception