9:00 Registration & Coffee
9:25 Welcome and Introduction by Richard Henderson, Laboratory of Molecular Biology, MRC, UK
Session I – RNA Dynamics
Chair: Maria Flocco, Co-Chair: Stephen McLaughlin
9:30 Frédéric Allain, ETH, Zurich, Switzerland:
FUS phase separation, RNA binding and aging as studied by NMR spectroscopy
10:00 David Lilley, University of Dundee, UK:
The extent of RNA catalysis – are there any limits ?
10:30 Katya Petzold, Karolinska Institute, Sweden:
RNA structural changes and their biological impact by NMR
11:00 Coffee Break
Session II – Imaging Across Scales
Chair: Geoff Holdgate, Co-Chair: Chris Johnson
11:30 Andreas Frutiger, Lino Biotech, Zurich, Switzerland:
Label-free interaction analysis in complex samples – focal Molography enables novel applications in bioprocessing, drug discovery and diagnostics
12:00 Tanmay Bharat, Laboratory of Molecular Biology, MRC, UK:
Understanding physiological processes in bacterial cells using cryo-EM
12:30 Jorge Bernardino de la Serna, Imperial College London, UK:
Imaging Cholesterol and its enriched domains spatiotemporally across scales
1:00 Lunch Break
Session III – Single Molecule Applications
Chair: David Rueda, Co-Chair: Geoff Holdgate
2:00 Nynke Dekker, Delft University of Technology, Netherlands:
Dynamic motion during loading and activation of the yeast replisome
2:30 Alice Pyne, University of Shefield, UK:
Uncovering the invisible complexities of the genome using atomic force microscopy
3:00 Ashley Nord, CNRS, Montpellier, France:
Single cell electrical characterization in bacteria
3:30 Coffee Break
Session IV – Computational approaches and Structure Prediction
Chair: Chris Johnson, Co-Chair: Maria Flocco
4:00 John Jumper, DeepMind, London, UK:
AlphaFold and its implications for understanding biology
4:30 Giulia Palermo, University of California Riverside, USA:
Dynamics and Mechanism of CRISPR-Cas9 through the Lens of Computational Methods
5:00 Rhiju Das, Stanford University, USA:
RNA modeling and design
5.30 Break
Keynote Lecture
Chair: Stephen McLaughlin, Co-Chair: David Rueda
5:40 David Baker, University of Washington, USA:
Protein design using deep learning
6.40 Closing Remarks by Jason Chin, Laboratory of Molecular Biology, MRC, UK
6:45 Drinks Reception